Objectives
This study sought to evaluate the safety of continuing trastuzumab in patients with
human epidermal growth factor receptor–positive breast cancer who developed mild cardiotoxicity.
Background
Cardiotoxicity is the most common dose-limiting ...
Objectives
This study postulated that antihypertensive therapy with renin-angiotensin-aldosterone
system (RAAS) inhibition may mitigate vascular endothelial growth factor inhibitor
(VEGFi)–mediated increases in blood pressure more effectively than ...
Objectives
This study quantified the change in blood pressure (BP) during antivascular endothelial
growth factor (VEGF) tyrosine kinase inhibitor (TKI) therapy, compared BPs between
TKIs, and analyzed change in BP during antihypertensive therapy.
...
Objectives
The purpose of this study was to investigate whether pre-diagnosis exercise reduces
the risk of subsequent cardiovascular events (CVEs) in women with primary breast cancer.
Background
Cardiovascular disease (CVD) is the leading ...
Objectives
This study sought to assess the effects of neurohormonal therapies in preventing cardiotoxicity
in patients receiving chemotherapy.
Background
Various cardioprotective approaches have been evaluated to prevent chemotherapy-related
...
Objectives
The authors performed a systematic review and meta-analysis of randomized and nonrandomized
trials on the efficacy of dexrazoxane in patients with breast cancer who were treated
with anthracyclines with or without trastuzumab.
Background
...
Objectives
This study investigated how different concentrations of doxorubicin (DOX) can affect
the function of cardiac cells. This study also examined whether activation of prokineticin
receptor (PKR)-1 by a nonpeptide agonist, IS20, prevents DOX-...
Cardiovascular (CV) toxicity from cancer therapy is a significant and growing concern.
Conventional oncology clinical trial designs focused solely on cancer treatment efficacy
have not provided sufficient information on both CV risk factors and ...
AL amyloidosis results from clonal production of immunoglobulin light chains, most
commonly arising from a clonal plasma cell disorder. Once considered a nearly uniformly
fatal disease, prognosis has improved markedly over the past 15 years, ...