JACC: Basic to Translational Science

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Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models
State-of-the-Art Review
- Willem B. van Ham,
- Saskia C.A. de Jager,
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease
Original Research - Preclinical
- Wenhao Han,
- Jinghong Zhao,
Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca²⁺ Overload
Original Research - Preclinical
- Ne N. Wu,
- Jun Ren,
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury
Original Research - Preclinical
- Hiroko Deguchi Miyamoto,
- Hiroyuki Tsutsui,
Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress
Original Research - Clinical
- Yihong Chen,
- Jan Nilsson,
A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants
Original Research - Clinical
- Fady I. Malik,
- Scott D. Solomon,

Just Accepted

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Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation
Clinical Research
- Mustafa I. Ahmed,
- Louis J. Dell’Italia,
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction
Clinical Research
- Dennis D. Wang,
- Kevin D. O’Brien,
Human Cardiac Pericytes are Susceptible to SARS-CoV-2 Infection
Leading Edge Translational Research
- Brittany D. Brumback,
- Stacey L. Rentschler,
Distinct Mechanisms for Increased Cardiac Contraction Through Selective Alteration of Either Myosin or Troponin Activity
New Research Paper
- Rohit R. Singh,
- Brandon L. Ason,
Neprilysin Inhibitors in Heart Failure: The Science, Mechanism of Action, Clinical Studies, and Unanswered Questions
State-of-the-Art Review
- Biykem Bozkurt,
- Savitri Fedson,
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction
Preclinical Research
- Gang Li,
- Stacey L. Rentschler,

JACC: Heart Failure Journal Club | June 18, 2020

Editor-in-Chief Dr. Douglas L. Mann, MD, FACC and Dr. Eugene Braunwald, MD, MACC

The June JACC: Heart Failure Virtual Journal Club features a presentation from Editor-in-Chief Dr. Douglas L. Mann, MD, FACC, and Dr. Eugene Braunwald, MD, MACC on the HFN-LIFE trial. The recording also includes discussion with members of the Journal editorial board, and an question and answer session with participants.

JACC: Basic to Translational Science - Effect of Crizanlizumab, a P-selectin Inhibitor, in COVID-19: A Placebo-Controlled, Randomized Trial

Douglas Mann

December 27, 2021
JACC: Basic to Translational Science - Role of oxidative stress and autophagy in thoracic aortic aneurysms

Douglas Mann

October 25, 2021
JACC: Basic to Translational Science - Human atherosclerotic plaque progression is dependent on apoptosis according to bomb-pulse 14C dating

Douglas Mann

October 25, 2021
JACC: Basic to Translational Science - Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction

Douglas Mann

July 26, 2021
JACC: Basic to Translational Science - Myopathic cardiac genotypes increase risk for myocarditis

Douglas Mann

July 26, 2021

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