VISCERAL ADIPOSITY IS A SIGNIFICANTLY STRONGER PREDICTOR OF DIABETES INCIDENCE IN MEN THAN IN WOMEN
Visceral adiposity is a paramount risk factor for the development of type 2 diabetes. Whether it equally increases diabetes risk in men and in women is not known and is addressed in the present study.
We prospectively recorded diabetes incidence in a large high-risk cohort of 1142 nondiabetic patients, including 755 men and 387 women who were undergoing coronary angiography for the evaluation of established or suspected coronary artery disease. Visceral adiposity was measured with the validated visceral adiposity index using waist circumference, serum triglycerides, age and gender to diagnose this metabolic abnormality; diabetes was diagnosed according to ADA criteria.
At baseline, visceral adiposity did not differ significantly between men and women (p=0.247). Prospectively, 133 (10.4 %) of our patients newly developed diabetes during a follow-up period of 3.7±0.9 years. Visceral adiposity significantly predicted the incidence of diabetes in men but not in women both univariately (ORs 1.71 [1.40-2.10]; p<0.001 and 1.09 [0.81-1.49]; p=0.565, respectively) and after multivariate adjustment including fasting plasma glucose (ORs 1.56 [1.24-1.97]; p<0.001 and 1.05 [0.75-1.46]; p=0.790, respectively). Interaction terms visceral adiposity x gender were significant both for univariate and for multivariate analyses (p<0.001 and p=0.017, respectively), indicating that visceral adiposity was a significantly stronger predictor of diabetes among men than among women.
We conclude that in angiographied coronary patients visceral adiposity is a significantly stronger predictor of diabetes incidence in men than in women.
Poster Hall, Hall A/B
Sunday, March 11, 2018, 9:45 a.m.-10:30 a.m.
Session Title: The Not So Sweet Truth: Latest Insights in Insulin Resistance and Diabetes For Preventive Cardiology
Abstract Category: 32. Prevention: Clinical
Presentation Number: 1212-410